実用的オリゴ糖合成の可能性を秘めた糖質関連酵素の立体構造

DOI:10.15011//jasma.34.340109
Int. J. Microgravity Sci. Appl. 2017p340109
論文著者
伏信 進矢
所属組織
東京大学大学院農学生命科学研究科
要約
Some sugars or carbohydrates have been known to possess health-promoting functions and widely used as food additives. Glycoside Hydrolases (GHs) have been widely utilized for preparing those carbohydrate products but they basically catalyze cleavage or transfer of glycosidic bonds. Glycoside phosphorylases (GPs) and glycosynthases can efficiently catalyze elongation of glycosidic bonds and have potential for practical oligosaccharide synthesis. We have been studying structural basis of various carbohydrate-active enzymes, focusing on anomer-inverting GPs and glycosynthases. Here I review significance of the structural studies and discuss demand of high-quality protein crystallization technology in this research field.
Keyword(s)
Glycoside Hydrolase, Glycoside Phosphorylase, Glycosynthase
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Received 22 November 2016, Accepted 13 December 2016, Published 31 January 2017

© The Japan Society of Microgravity Applicaiton

この投稿文は次の言語で読めます: 英語

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